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Spatial distribution of the tau cross-eigenimage in CN and LMCI groups.

Spatial distribution of the tau cross-eigenimage in CN and LMCI groups. The β-amyloid scores appear to have stronger distance-correlation with tau for the CN group, particularly within the entorhinal cortex.

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In contrast to the β-amyloid cross-eigenimage maps, this figure shows that the tau cross-eigenimage carries stronger distance-correlation values in LMCI than in CN subjects, particularly within the entorhinal cortex.

The striking differences shown in the cross-correlation spatial patterns between CN and LMCI groups is a compelling argument to claim that the spatial dependency between β-amyloid and tau seems to follow distinctive patterns that depend on the cognitive status.

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