Preclinical WebsiteClinical Website
Table of Contents

Table of Contents

Abstract
01. Presentation Overview
Presentation
01. Introduction02. CDCA Methods 103. CDCA Methods 204. CDCA Methods 305. CDCA Methods 406. CDCA Methods 507. CDCA - Spatial Loadings08. CDCA - Scores09. Cross-Eigenimages10. Amyloid Cross-Eigenimages 111. Tau Cross-Eigenimages 112. Amyloid Cross-Eigenimages 213. Tau Cross-Eigenimages 214. Summary
Spatial distribution of the β-amyloid cross-eigenimage in CN and LMCI groups.

Spatial distribution of the β-amyloid cross-eigenimage in CN and LMCI groups. The tau scores appear to have stronger distance-correlation with β-amyloid for the CN group.

--:--

In order to investigate the dependency of the tau-amyloid association on the subject’s clinical condition, the Canonical Distance Correlation Analysis was re-assessed for each of the subpopulations of Cognitively Normal and Late Mild Cognitively Impairment subjects.

The CDCA revealed that the first canonical component accounted for 29.41% and 28.90% of the total co-variability in the CN and LMCI groups, respectively.

The figure shows that the β-amyloid cross-eigenimage appears to be much stronger in CN than in LMCI, where the loadings cover extended areas of the medial prefrontal cortex, posterior cingulate cortex, and precuneus.

We use necessary cookies to make our site work. We also use other cookies to help us make improvements by measuring how you use the site or for marketing purposes. You have the choice to accept or reject them all. For more detailed information about the cookies we use, see our Privacy Notice.