Spatial loadings for the first canonical correlation component. The strongest positive weights in the tau eigenimage are located in areas of the entorhinal cortex, lateral inferior temporal gyri, and fusiform gyri, while the strongest negative weights corresponding to the FDG map appeared within the lateral inferior temporal gyri, angular gyri, and posterior cingulate cortex.
An SVD analysis was applied to a matched sample of FDG and tau PET images from the ADNI dataset.
The first canonical component accounted for 21.49% of the total co-variability between FDG and tau.
The strongest positive weights in the first tau eigenimage correspond to the entorhinal cortex, the lateral inferior temporal gyri, the fusiform gyri, the bilateral angular gyrus, as well as areas of the posterior cingulate cortex.
Thus, such regions appear to be negatively correlated to the strongest negative loads in the FDG eigenimage, which correspond to the lateral inferior temporal gyri, angular gyri, and small areas within the posterior cingulate cortex.