Several bilateral seed regions were identified as local maxima in the first tau eigenimage. A detailed seed-based correlation analysis is presented for two seed regions: the left fusiform gyrus (LFUSI) and the right angular gyrus (RANG), which were regions that showed distinct amyloid-glucose metabolism correlation patterns in one of our previous studies.

Panels A and B in the figure show the spatial distribution of the tau pattern of spread, or “tau network” associated with the left fusiform and the right angular seeds, respectively. As expected, strong correlation values were obtained around the seed locations, which are indicated by the black arrows.

Notice that the seed-based tau network relative to the LFUSI seed appears to be strong and spatially extended beyond the fusiform gyrus and covers large bilateral areas of the temporal-parietal lobes and precuneus.

In contrast, the RANG tau network is particularly strong within the right angular gyrus itself and within the bilateral precuneus and posterior cingulate cortex.