The RANG and LFUSI tau measurements show a distinct local-to-distributed cross-correlation pattern with glucose metabolism.

Panel A in the figure shows that the correlation pattern corresponding to the LFUSI tau seed is composed of strong negative correlations with glucose metabolism in the lateral inferior-temporal gyri, fusiform gyri, angular gyri, and precuneus, which resembles the significant regions obtained with the spatially distributed SVD-based tau scores.

In contrast, local tau in the RANG seed (seen in Panel B) was weakly related to glucose metabolism, and the strongest negative correlations were observed only within the right angular gyrus itself and the posterior cingulate cortex.

Notice also that the local tau in the RANG seed was associated with an increase of glucose metabolism in areas spread across the cortex.