The figure shows how the relationship between glucose metabolism and the SVD-based tau scores is continuously modulated by the spatially distributed β-amyloid scores. We can easily observe an evident overall tau-related reduction in glucose metabolism associated with the increase in β-amyloid levels.

The figure shows that for low levels of β-amyloid, the areas showing the stronger negative tau-FDG correlations correspond to the lateral inferior temporal gyri, angular gyri, precuneus, and posterior cingulate cortex. Notice also small areas of increase in glucose metabolism, particularly in the pars opercularis. 

With the increase of β-amyloid from SUVR=1. to SUVR=1.75, there is an evident increase in the strength of the negative correlations between FDG and tau, as well as a decrease in extent and strength in those small areas associated to a tau-related increase in glucose metabolism.

In fact, for very high values of β-amyloid, the spatial extent and strength of the negative correlations are noticeable for most of the cortex.