Associations between local tau and glucose metabolism modulated by spatially distributed β-amyloid. The LFUSI tau seed shows spatially extended negative correlations between tau and glucose metabolism. The negative correlations for the RANG tau seed appear restricted to the left lateral inferior temporal-parietal regions. Large areas of increase in glucose metabolism are associated with RANG tau after adjustment for the β-amyloid effect.
The inclusion of SVD-based β-amyloid measures in our models decreases the strength and spatial extent of the local-to-distributed patterns of the tau-glucose metabolism relationship.
In fact, the stronger and more spatially extensive negative correlations between tau and glucose metabolism after removal of the distributed β-amyloid scores corresponded to the LFUSI seed, and are only particularly strong within the left fusiform gyrus itself and the left lateral inferior temporal gyrus.
On the other hand, the weak negative correlations for the RANG case appear restricted to the left lateral inferior temporal-parietal regions, while much larger areas of positive correlations were enhanced throughout the brain.