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Table of Contents

Table of Contents

Abstract
01. Landing Page
Presentation
01. Introduction02. Patient Demographics & Features at Baseline03. MRI Deformation Processing04. Thalamus Deformations in PD05. Thalamus Deformations in Controls & Prodromal06. Volumetry vs. Surface Deformations07. Sample Size Power Analysis08. Several ROIs Deformations09. DaTscan SBR in PD10. Midbrain Deformations Predicts DaTscan SBR11. Accuracy of DaTscan SBR Predictions12. Summary
Longitudinal Changes volume and Surface for Thalamus

Longitudinal changes in volume and surface deformations for the Thalamus. While the volumetric measurement remains almost stable over time, the Thalamus deformations are able to capture early longitudinal changes in local atrophy.

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A Statistical ROI (StatROI) measure of surface deformation in the Thalamus was defined by averaging deformation maps over the spatial set of statistically significant clusters detected at 48 months in the PD group. As opposed to the volume measure, this surface StatROI deformation measure showed a consistent decrease over time for the PD group.

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