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Table of Contents

Table of Contents

Abstract
01. Landing Page
Presentation
01. Introduction02. Patient Demographics & Features at Baseline03. MRI Deformation Processing04. Thalamus Deformations in PD05. Thalamus Deformations in Controls & Prodromal06. Volumetry vs. Surface Deformations07. Sample Size Power Analysis08. Several ROIs Deformations09. DaTscan SBR in PD10. Midbrain Deformations Predicts DaTscan SBR11. Accuracy of DaTscan SBR Predictions12. Summary
Longitudinal analysis of Thalamus deformations in Controls and Prodromal

Spatial representation of the statistically significant changes in deformations of the Thalamus after 48 months of the baseline visit for Controls and Prodromal subjects. The negative sign changes do not spatially expand over time as in the case of PD subjects, reflecting both the sensitivity and specificity of the surface deformation metric for the diagnosis and tracking of PD.

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The statistically significant changes over 48 months in local surface deformations of the Thalamus for both Controls and Prodromal groups were weaker and less spatially extended as compared with the case of PD subjects.

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