Cohen’s d effect sizes are shown for PSPRS clinical scores (purple), planimetric MRPI measures (green), regional diffusivity metrics (orange), and regional atrophy measures (blue). The dotted line at 0.8 indicates the threshold for a large effect size.
The graph displays a comparison of Cohen’s d effect sizes across multiple modalities for assessing disease progression in PSP. PSPRS clinical scores (purple) are shown alongside planimetric MRPI (green), regional diffusivity measures (orange), and regional atrophy measures (blue). While PSPRS and MRPI demonstrated moderate sensitivity to change, regional atrophy measures showed consistently higher effect sizes across multiple brain regions. This data suggests that regional atrophy may offer improved sensitivity for detecting progression, making it a valuable tool for clinical monitoring and trial endpoints.