Control Subjects PSP Subjects
Regional diffusion MRI metrics (RD: radial diffusivity; FW: free water) from baseline to 6 and 12 months are shown for healthy controls and PSP subjects across a subset of the regions that show the greatest changes over a 12 month period.
The t-statistics and p-values for the regional diffusion MRI metric data modeled between visits (6 and 12 months compared to baseline) for the PSP group. The statistical analysis model uses both age and sex as covariates. The t-statistics are highlighted from green (low) to red (high) for regions that show significant increases in the diffusion MRI metric (MD: mean diffusivity; FW: free water).
These graphs demonstrate the percent regional change in diffusion MRI metrics of selected white matter tracts, as well as cortical, subcortical, and cerebellar regions over a 12 month period. These regions demonstrate 5-10% increase in diffusion MRI metrics over this time period in the PSP group, compared to smaller changes observed in the same regions within the control population.
The table summarizes the t-statistics and p-values for the regional diffusion MRI metric changes. While all regions show statistically significant changes over the 12 month period, some regions, such as the caudate, striatum, and the anterior portion of the corpus callosum, are also significant after only 6 months.