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Table of Contents

Table of Contents

Presentation Overview
01. Presentation Overview
Presentation
01. Introduction02. Patient Features at Baseline 03. Image Processing Methods04. Voxelwise Atrophy Analysis05. Regional Volumetry06. Atrophy Sample Size Analysis07. Image Processing Methods - Diffusion MRI08. Voxelwise Diffusion MRI Analysis09. Regional Diffusion MRI Measures10. Diffusion MRI Sample Size Analysis11. Summary

CBD and PSP Subjects

Percent change in regional volumetric data from baseline to 6 and 12 months are plotted for both the CBD and PSP subjects across a subset of the cortical and subcortical regions. 

Percent change in regional volumetric data from baseline to 6 and 12 months are plotted for both the CBD (green) and PSP (orange) subjects across a subset of the cortical and subcortical regions. 

CBD Subject Regional Volumetry

The t-statistic and p-values for the regional volumetric data modeled between visits (6 and 12 months compared to baseline) per group.

The t-statistic and p-values for the regional volumetric data modeled between visits (6 and 12 months compared to baseline) per group. The regional data is normalized for intracranial volume, and the statistical analysis model uses both age and sex as covariates. The t-statistics are highlighted in red for regions that are expanding, and from green to purple for regions that show significant atrophy.

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These graphs demonstrate the regional atrophy comparing CBD and PSP subjects where we assessed the percent change in volume over a 12 month period. Of note is that in the cerebellar peduncles and brain stem the PSP subjects have greater atrophy demonstrating a 2-4% reduction in volume over this time period while having only limited cortical atrophy. In contrast, in the cortical regions (sensory, motor, frontal, and parietal), the CBD subjects have a greater rate of atrophy (3-5 % over 12 months). 

The table summarizes the t-statistics and p-values for the regional volumetric changes in CBD subjects. While all regions show statistically significant changes over the 6 and 12 month periods, the ventricular regions, thalamus, and sensory motor cortex are highly significant even at 6 months.

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