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Table of Contents

Table of Contents

Abstract
01. Abstract
Presentation
01. Introduction02. SPECT Image Processing03. PET Image Processing04. Patient Features at Baseline05. Voxelwise Exploratory SBR Analysis06. Regional DAT SBR Measures 07. Regional VMAT2 SBR Measures08. DAT & VMAT2 Sample Size Analysis09. Summary
Regional VMAT2 PET SBR trajectories

The change in regional SBR (VMAT2 PET) from baseline to 48 months in individuals with Parkinson’s disease are shown in the striatum and in subregions (putamen, caudate and pallidum). The occipital cortex is used as the reference region. The x-axis (in months) displays time since the first clinical visit. 

VMAT2 PET SBR t-statistic table

The t-statistics and p-values for the regional SBR (VMAT2 PET) data modeled between visits (12, 18, 24, and 48 months compared to baseline) in individuals with Parkinson’s disease. Scans were grouped with the timepoint corresponding to their visit label as provided by the PPMI database. The t-statistics are highlighted for each region ranging from red to green with increasing significance in the PET SBR reduction.

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The graphs show the regional change in striatal binding ratio (SBR) of VMAT2 PET data in striatal regions over a 48 month period in individuals with Parkinson’s disease. The occipital cortex was used as the reference region.

The table shows the t-statistics and p-values for the regional SBR (VMAT2 PET) data modeled between visits (12, 18, 24, and 48 months compared to baseline) in individuals with Parkinson’s disease. The t-statistics are highlighted for each region ranging from red to green with increasing significance in the PET SBR reduction.

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