The change in regional SBR (DAT SPECT) from baseline to 48 months in individuals with Parkinson’s disease are shown in the striatum and in subregions (putamen, caudate and pallidum). The occipital cortex is used as the reference region. The x-axis (in months) displays time from the first clinical visit, and all scans up to 6 months were included as baseline. Otherwise, scans were included if they were acquired 8 months before or 4 months after the 12, 24, and 48 months timepoints from first clinical visit.
The t-statistics and p-values for the regional SBR (DAT SPECT) data modeled between visits (12, 24, and 48 months compared to baseline) in individuals with Parkinson’s disease. The t-statistics are highlighted for each region ranging from red to green with increasing significance in the DAT SBR reduction.
The graphs show the regional change in striatal binding ratio (SBR) of DAT SPECT data in striatal regions over a 48 month period in individuals with Parkinson’s disease. The occipital cortex was used as the reference region. The table summarizes the t-statistics and p-values for the regional SBR changes, showing very significant changes in all regions in as little as 12 months. The linear mixed effects model included 101 participants that had up to 24 months follow-up, and 38 that had up to 48 months follow-up.
In both the graphs and the table, all striatal regions demonstrate similar levels of change, though the putamen appears to demonstrate the most significant changes. No obvious difference was observed in the longitudinal change between the anterior and posterior putamen, though the anterior putamen showed more significant changes.