The percent change in regional mean diffusivity (MD) from baseline to 6 and 12 months are shown for the three common FTD variant groups and the control group across a subset of the white matter, cortical, and subcortical regions.
The t-statistics and p-values for the regional diffusion MRI metric data modeled between visits (12 months compared to baseline) for the three common FTD variant groups. The statistical analysis model uses both age and sex as covariates. The t-statistics are highlighted from green to red for regions that show significant increase in the diffusion MRI metric (MD: mean diffusivity; FW: free water).
The graphs show the percent regional change in mean diffusivity (MD) of select regions over a 12 month period comparing the control group with groups suffering from the three most common FTD variants. In all regions shown, there was minimal to no change in the control population. The table summarizes the t-statistics and p-values for the regional diffusion metric changes, showing a wide range of white matter, cortical, and subcortical regions with statistically significant changes over the 12 month period in all three FTD groups.
In both the graphs and the table, many regions demonstrate similarly increased levels of change in all three variant groups, such as the caudate and the hippocampus. Compared to other FTD groups, the semantic variant (svPPA) group demonstrates greater changes in the amygdala, the temporal cortex, and white matter. In comparison, the behavioral variant (bvFTD) group shows greater change in frontal, and cingulate cortex and white matter, and the group with the non-fluent variant (nfvPPA) group has less localized change and is only slightly more affected than other groups in the corpus callosum.